138 ORTHOSTATIC CEREBRAL OXYGENATION AND THE RELATIONSHIP WITH SYMPTOMS, SUPINE HYPERTENSION AND ORTHOSTATIC HYPOTENSION

Abstract Background Cerebral hypoperfusion is implicated as a cause of orthostatic symptoms such dizziness and light-headedness. In older adults, Orthostatic Hypotension (OH) may co-exist with Supine Hypertension (SH), greater cerebral dysfunction being reported in those SH-OH. It remains unclear whether are indicative higher hypotensive burden adults. This study assessed oxygenation cohort adults experiencing symptoms, via an active stand challenge, well the relationship OH SH. Methods We utilized data from Wave 3 Irish Longitudinal Study on Ageing (TILDA). was continuously measured near infrared-spectroscopy, blood pressure Finometer. Logistic regression employed to assess hemodynamics sample (N=2,737, mean age=65 years [range: 54-93 years]). Models were adjusted for covariates age, sex, standing speed, medications, cardiovascular conditions. Results whole sample, 29% participants 13% experienced OH30 49% had Those who less likely have supine hypertension (OR=0.73, p<0.001), but more experience (OR=1.69, p=0.005). They also larger initial drop upon (β=-0.07%, p=0.006). However, not associated impaired recovery at 30 seconds, or minutes after standing. Conclusion somewhat protective against there still relatively large discord between during orthostasis. implies asymptomatic be risk factor adverse outcome. There need routine screening SH